Antilichaamvasteerde

An **antilichaamvasteerde** (also known as an *immunoglobulin G (IgG) subclass deficiency* or *IgG subclass deficiency*) refers to a condition characterized by abnormally low levels of one or more subclasses of immunoglobulin G (IgG) antibodies. IgG antibodies are a critical component of the immune system, playing a key role in fighting bacterial and viral infections. The four subclasses of IgG—IgG1, IgG2, IgG3, and IgG4—each have distinct functions, and deficiencies in one or more of these subclasses can impair immune responses.

This condition is often identified through blood tests that measure the levels of each IgG subclass. While some individuals may have low IgG subclass levels without experiencing symptoms, others may develop recurrent infections, particularly of the respiratory and sinus tracts. Common symptoms include frequent ear infections, sinusitis, pneumonia, and other bacterial infections. The severity of symptoms varies depending on the extent of the deficiency and the individual’s overall immune function.

Antilichaamvasteerde is typically diagnosed after other causes of recurrent infections, such as common variable immunodeficiency (CVID) or selective IgA deficiency, have been ruled out. Treatment often involves preventive measures such as vaccinations (particularly pneumococcal and Haemophilus influenzae vaccines), antibiotics for infections, and, in some cases, intravenous immunoglobulin (IVIG) therapy to supplement antibody levels. Lifestyle adjustments, such as avoiding exposure to known pathogens, may also be recommended.

The condition is generally not inherited but can sometimes occur spontaneously or be associated with other immune system disorders. While antilichaamvasteerde is not life-threatening in most cases, proper management is essential to prevent complications from recurrent infections. Regular monitoring by an immunologist or infectious disease specialist is often advised for individuals diagnosed with this condition.