IgGIgG1

IgGIgG1 refers to an immunoglobulin G1 (IgG1) antibody. IgG antibodies are the most abundant type of antibody found in the blood and lymph fluid. They play a crucial role in the adaptive immune response, helping to neutralize pathogens like viruses and bacteria. The IgG class is further divided into four subclasses: IgG1, IgG2, IgG3, and IgG4. IgG1 is the most prevalent subclass, making up about 65-70% of total serum IgG.

IgG1 antibodies are particularly important for their ability to activate the complement system and engage with effector cells, such as macrophages and neutrophils. This engagement helps to clear pathogens from the body through processes like phagocytosis and antibody-dependent cell-mediated cytotoxicity (ADCC). They are also adept at crossing the placenta, providing passive immunity to the fetus. The specific amino acid sequence within the Fc region of an IgG1 antibody dictates its interaction with Fc receptors on immune cells and its ability to trigger these effector functions. Therapeutic antibodies designed to target diseases often leverage the properties of IgG1 for enhanced efficacy.