Adenosineinduced

Adenosine-induced refers to effects that are produced by adenosine, a purine nucleoside involved in cellular energy transfer and signaling. In pharmacology and medicine, adenosine is used both as a diagnostic and therapeutic agent. It acts on four G protein–coupled adenosine receptors (A1, A2A, A2B, A3) found throughout the body, including the heart, vessels, lungs, and nervous system. The term encompasses a range of physiological responses and drug‑induced effects that result from receptor activation.

In the heart, activation of A1 receptors slows atrioventricular (AV) nodal conduction, which can transiently produce AV block or bradycardia. This property underlies the use of adenosine to terminate certain forms of supraventricular tachycardia. In the vasculature, A2A receptor stimulation leads to vasodilation, particularly of coronary arteries, and can cause a brief drop in blood pressure and facial flushing during clinical use. Adenosine can also affect the airways and inflammatory processes, with bronchoconstriction observed in some individuals with asthma or airway hyperreactivity through mechanisms involving other adenosine receptor subtypes.

Clinically, adenosine is used as a pharmacologic stress test to assess myocardial perfusion and as a rapid-acting antidysrhythmic to interrupt certain SVTs. Adverse or adenosine-induced effects are typically transient and include chest discomfort, facial flushing, dyspnea or throat tightness, and, less commonly, bronchospasm, hypotension, or brief arrhythmias. Safety considerations include avoiding use in patients with high-grade AV block or certain conduction disorders without a pacemaker, and exercising caution in asthma or severe reactive airway disease.