AcrBmediated
AcrB-mediated efflux refers to the action of the AcrB protein, a central component of the AcrAB-TolC tripartite efflux pump in many Gram-negative bacteria. This system transports a broad range of substrates, including many clinically relevant antibiotics, out of the cell, contributing to multidrug resistance by reducing intracellular drug concentrations.
AcrB is a homotrimer located in the inner membrane. Each protomer cycles through conformational states in a
AcrB substrates are diverse, including beta-lactams, chloramphenicol, tetracyclines, fluoroquinolones, macrolides, and dyes and detergents. The presence
Efforts to counter AcrB-mediated resistance include research into efflux inhibitors that block AcrB function, genetic mutations