ATRmediated
ATRmediated refers to cellular processes governed by the ATR kinase signaling pathway in response to DNA replication stress and DNA damage. The ATR-ATRIP complex is recruited to sites where single-stranded DNA is coated with RPA, such as stalled replication forks or resected double-strand breaks. Activation is amplified by the ATR activators TopBP1 and ETAA1, leading to phosphorylation of downstream effectors, most notably the checkpoint kinase CHK1. Through CHK1 and other substrates, ATR signaling enforces cell cycle checkpoints and coordinates DNA repair.
Key outcomes of ATR-mediated signaling include stabilization of stalled replication forks, suppression of late origin firing,
Genetic disruption of ATR often results in severe defects or lethality in model organisms, and in humans
Research on ATR-mediated signaling continues to define its spectrum of substrates and its interactions with fork