AP1responsive
AP1responsive is a term used in molecular biology to describe genes or regulatory elements whose transcription is modulated by the activator protein 1 (AP-1) transcription factor complex. AP-1 is a dimer formed from Fos and Jun family proteins and binds to specific DNA sequences known as AP-1 response elements. The binding sites are commonly described by a TGACTCA-like consensus, though variations occur across promoters and enhancers. Genes labeled as AP1responsive typically change their expression levels when AP-1 activity is stimulated.
Activation of AP-1 is controlled by signaling pathways such as MAP kinases, including ERK, JNK, and p38.
Identification of AP1responsive genes relies on experimental approaches that compare gene expression before and after AP-1
In practice, AP1responsive genes are associated with diverse cellular processes, including proliferation, differentiation, migration, and inflammatory