AM2201

AM2201, also known as N-0135 or 8-quinolinyl 1-pentyl-1H-indole-3-carboxylate, is a synthetic cannabinoid. It is structurally related to JWH-018 and belongs to the indole-3-carboxylate class of compounds. AM2201 was developed by Alexandros Makriyannis and his research group at Northeastern University as a tool for scientific research, specifically to study the cannabinoid receptors CB1 and CB2. It acts as a potent agonist at these receptors.

First synthesized and reported in scientific literature around 2009, AM2201 gained notoriety as a recreational drug, often found in "spice" or "herbal incense" products. Due to its psychoactive effects and potential for harm, it has been subject to legal controls in many countries. Its pharmacological profile indicates a high affinity for the CB1 receptor, which is primarily responsible for the intoxicating effects of cannabis. The metabolism of AM2201 involves breakdown into various metabolites, some of which may also possess activity at cannabinoid receptors. Research into its effects and long-term consequences is ongoing, with a focus on its toxicology and potential risks associated with its illicit use.