ABHD9

ABHD9 (alpha/beta hydrolase domain-containing 9) is a protein encoded by the ABHD9 gene in humans. It belongs to the alpha/beta hydrolase domain-containing (ABHD) superfamily, a large group of enzymes that often function as serine hydrolases involved in lipid metabolism and signaling.

Protein structure and activity: ABHD9 is predicted to adopt the alpha/beta hydrolase fold and is anticipated to contain motifs characteristic of serine hydrolases, including a catalytic serine residue. The exact active-site arrangement and substrate specificities have not been conclusively demonstrated in a biochemical context, and its enzymatic activity remains to be experimentally defined.

Expression and localization: ABHD9 transcripts are detected in multiple human tissues, with expression reported across various organs in available transcriptome data. The precise subcellular localization is not firmly established, and, as with many ABHD family members, may involve membrane-associated or cytosolic compartments.

Function and research status: The physiological role of ABHD9 is not well characterized. While members of the ABHD family participate in lipid hydrolysis and lipid signaling pathways, specific substrates, reaction mechanisms, and biological functions for ABHD9 have not been definitively identified. Ongoing research seeks to clarify its enzymatic activity, regulatory controls, and potential involvement in metabolic processes.

Evolution and nomenclature: ABHD9 is conserved across vertebrates, reflecting its inclusion in the broader ABHD gene family. The protein name reflects its membership in this family and its predicted enzymatic lineage.

Clinical relevance: There are no widely established disease associations directly linked to ABHD9 in current literature. Research remains exploratory, and ABHD9 may be investigated for potential roles in metabolic signaling and lipid biology.