8oxodG
8oxodG, short for 8-oxo-2'-deoxyguanosine (also written 8-oxo-dG), is a DNA lesion arising from oxidative modification of guanine. It is one of the most frequently studied forms of oxidative DNA damage and serves as a common marker of cellular oxidative stress. The lesion can form directly in DNA or result from the incorporation of oxidized deoxynucleotide triphosphates, such as 8-oxodGTP, during DNA replication.
Formation and mutagenicity: Reactive oxygen species generated during cellular metabolism or environmental exposures attack guanine at
DNA repair: The primary repair pathway for 8-oxoG is base excision repair. The enzyme OGG1 glycosylase recognizes
Measurement and significance: 8oxodG is used as a biomarker of oxidative stress and aging. It is measured
Clinical and biological relevance: Elevated 8-oxoG/8oxodG levels have been reported in aging, cancer, neurodegenerative and inflammatory