4kinases
4kinases is a term used in speculative biology and some science fiction narratives to denote a quartet of protein kinases that function together as a regulatory module in cellular signaling. In these models, the four kinases share evolutionary origin and form a co-regulated unit that coordinates phosphorylation events. Each member typically has a conserved catalytic kinase domain, while variable regulatory regions determine substrate specificity and control by phosphorylation, lipid binding, or protein interactions. The quartet is commonly depicted as encoded by a small, tightly linked gene cluster with coordinated expression.
Proposed modes of action include sequential activation, cross-activation, or parallel phosphorylation of distinct substrates, producing integrated
As a conceptual framework, 4kinases helps explore how multi-kinase modules could coordinate complex cellular processes such