20hydroxyecdysone

20-Hydroxyecdysone, commonly abbreviated as 20E, is a polyhydroxylated steroid classified as a phytoecdysteroid. It is found in a variety of plants, including spinach and several herbs, where it is one of the natural ecdysteroids produced as secondary metabolites. 20E is also studied for its potential use as a dietary supplement in some markets, where it is marketed for athletic performance or body composition benefits.

In insects, 20E acts as the molting hormone. It binds to the ecdysone receptor (EcR) in complex with the ultraspiracle protein (USP), triggering gene expression programs that regulate molting, metamorphosis, and development. The receptor system and downstream effects are specific to arthropods; there is no evidence that 20E operates in the same way through human steroid receptors.

In humans, the pharmacology of 20E is not well established. It does not appear to bind to classical human steroid hormone receptors in a meaningful way, and claimed anabolic or performance-enhancing effects are not supported by robust clinical evidence. Human trials testing 20E for strength, endurance, or fat loss are limited and have yielded inconsistent results, with no definitive demonstration of benefit.

Regulatory status and safety: 20E is not approved as a drug and is sold as a dietary supplement in many jurisdictions. Safety at typical supplement doses is generally considered acceptable, though long-term safety data are limited and product quality can vary. As with all supplements, consumers should exercise caution and consider consulting healthcare professionals before use.