zincalkyl
Zincalkyl refers to organozinc compounds where a carbon atom of an alkyl or aryl group is directly bonded to a zinc atom. These compounds are a versatile class of reagents in organic synthesis. They are generally less reactive than their Grignard or organolithium counterparts, which can be advantageous in certain reactions, allowing for greater selectivity.
The preparation of zincalkyls can be achieved through several methods. One common approach involves the reaction
Zincalkyls are widely employed in cross-coupling reactions, notably the Negishi coupling. In this palladium-catalyzed reaction, a
Beyond coupling reactions, zincalkyls can also participate in conjugate additions to alpha,beta-unsaturated carbonyl compounds and additions