transfusiondependent
Transfusion-dependent is a medical term used to describe patients who require ongoing regular blood transfusions to maintain adequate red blood cell mass and organ function. Dependence is typically defined by a consistent need for scheduled transfusions over weeks to months, though exact thresholds vary by condition and guideline.
Common causes include congenital disorders such as beta-thalassemia major and Diamond-Blackfan anemia, and acquired conditions such
Management involves a regular transfusion program to sustain target hemoglobin or hematocrit levels, with adjustments for
Long-term options may include hematopoietic stem cell transplantation or, in some conditions, gene therapy, which can