solupohjainen

Solupohjainen is a Finnish adjective used to describe something that is based on living cells or derived from cells. It is common in biology, medicine, biotechnology, and related fields to distinguish approaches, models, or systems that rely on cells from those that do not.

In practical use, solupohjaiset kokeet refer to experiments that involve living cells to assess outcomes such as viability, cytotoxicity, signaling pathways, gene expression, or metabolic activity. The term also appears in descriptions of cell-based models of disease, 2D or 3D cell cultures, and advanced systems like organ-on-a-chip or cell-based sensors. In clinical and therapeutic contexts, solupohjainen terapia denotes therapies that use cells, such as stem cell treatments or tissue-engineered products, rather than purely chemical compounds.

The concept is often contrasted with soluvapaa or soluvapaa-analyyse (cell-free) approaches, which use purified biomolecules or acellular systems instead of whole cells. The choice between solupohjainen and cell-free methods depends on the research question, needed physiological relevance, and regulatory considerations. While cell-based methods can provide more realistic biological responses, they also introduce greater variability, complexity, and ethical or sourcing considerations related to the cells used.

Etymology-wise, solupohjainen combines solu (cell) with pohjainen (based). In Finnish scientific usage, it appears across disciplines, including solupohjainen diagnostiikka (cell-based diagnostics), solupohjainen tutkimus, and solupohjainen terapia, reflecting the central role of cells in many modern biomedical approaches.