sinecatechins

Sinecatechins are a standardized extract derived from the leaves of Camellia sinensis (green tea). The preparation is rich in catechins, a group of polyphenolic compounds, with epigallocatechin gallate (EGCG) among the major constituents. Sinecatechins are used medically as a topical agent and are available in a 15% ointment formulation under brand names in various markets.

Clinical use centers on the treatment of external genital and perianal warts caused by human papillomavirus (HPV). It is applied topically to affected skin.

The typical regimen involves a 15% sinecatechins ointment applied to the lesions three times daily for up to 16 weeks. The exact duration may depend on response and tolerance. The mechanism is not fully understood, but catechins are thought to have antiviral and immunomodulatory activities that may help clear infected cells, along with anti-inflammatory effects.

Common adverse effects are local skin reactions at the application site, including redness, itching, burning, and pain. Rare cases of dermatitis or hypersensitivity have been reported. The preparation should be used only on intact skin and kept away from eyes, mucous membranes, and healthy surrounding tissue.

Regulatory status: In the United States, a sinecatechins 15% ointment (Veregen) is approved for treating external genital and perianal warts. Availability and labeling vary by country.