selftolerance
Self-tolerance is the ability of an organism’s immune system to distinguish self from non-self and to prevent immune responses against the body’s own tissues. It aims to preserve defense against pathogens while avoiding injury to host cells and organs.
Central tolerance occurs during the development of immune cells. In the thymus, developing T cells that strongly
Peripheral tolerance acts on self-reactive cells that escape central mechanisms. It includes anergy, where T or
Breakdown of self-tolerance can lead to autoimmune diseases, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis,
Understanding self-tolerance informs therapies in transplantation and autoimmunity, such as strategies to induce antigen-specific tolerance or