sctC
sctC is a gene encoding the secretin protein SctC, a core component of the bacterial type III secretion system (T3SS). It codes for an outer membrane protein that forms part of the secretin ring, a multimeric channel in the outer membrane through which effector proteins are secreted into host cells. SctC is typically found in pathogenic Gram-negative bacteria and is essential for the assembly and function of the T3SS basal body.
Functionally, SctC assembles into a multimeric complex that spans the outer membrane, creating the outer membrane
In terms of homologs and naming, many bacteria use the sctC designation for the secretin subunit. In
Structure and biogenesis are characteristic of bacterial secretins: SctC proteins are typically large, with periplasmic and
Significance: SctC is a key virulence determinant in many pathogens and represents a potential target for strategies