rosavins

Rosavins are a group of phenylpropanoid glycosides found in the plant Rhodiola rosea, widely used in traditional medicine and modern herbal supplements for their purported adaptogenic properties. The term typically refers to a trio of closely related compounds: rosavin, rosarin, and rosin, which occur together in the rhizomes and roots of Rhodiola rosea.

Chemically, rosavins are glycosides formed from cinnamyl alcohol derivatives linked to a sugar moiety. They are commonly analyzed and quantified in Rhodiola extracts as marker compounds to assess quality and potency, together with salidroside, another major active constituent.

In herbal products, rosavins are often used to standardize extracts. Many Rhodiola rosea preparations are labeled with a stated rosavins content, and some brands pursue a standard such as 3% rosavins (calculated as rosavin, rosarin, and rosin) and 1% salidroside, though formulations vary. The rosavin group is believed to contribute to the plant's adaptogenic profile, potentially supporting fatigue resistance and mood, but clinical evidence remains mixed and is generally inconclusive.

Pharmacology and safety: Most research has focused on whole plant extracts rather than isolated rosavins. Proposed mechanisms include modulation of stress-response pathways and monoaminergic systems, along with antioxidant effects. Rosavins are usually well tolerated, with common side effects being mild gastrointestinal discomfort or insomnia in rare cases; possible interactions with antidepressants have been suggested. As with other herbal supplements, quality variability and lack of standardization can affect efficacy and safety.