refrattaria
Refrattaria is the feminine singular form of the Italian adjective refrattario, used to describe things that are highly resistant to heat or to treatment. In Italian, the property is often applied to materials or conditions, with the feminine form matching the noun, for example argilla refrattaria (refractory clay) or pietra refrattaria (refractory stone). The plural form is refrattarie.
In materials science and construction, refrattaria commonly refers to substances capable of withstanding very high temperatures
In medicine and biology, refrattaria can describe states or diseases that do not respond to standard therapies.
Etymology traces refrattaria to Latin refractarius, via Italian refrattario, with the sense shift toward stubborn or