redoxcontrolled

Redox-controlled, or redox-controlled, describes systems in which the oxidation–reduction (redox) state of a component acts as a central control parameter that modulates properties or behavior. In such systems, changes in oxidation state can trigger structural rearrangements, alter binding affinity, switch conductivity, or adjust catalytic activity. Redox control is achieved by applying electrical potential in an electrochemical cell or by adding chemical oxidants or reductants that shift the redox balance. The redox state thus functions as a reversible switch.

Mechanistically, redox-controlled systems rely on redox-active centers—such as metal centers, organic dyes, or conductive polymers—that change electron density, charge, or geometry upon oxidation or reduction. These changes can influence intermolecular interactions, conformations, and transport properties, enabling responsive behavior.

Applications and examples include redox-controlled polymers and hydrogels that swell, collapse, release cargo, or alter mechanical properties in response to redox triggers; redox-switchable catalysts whose activity or selectivity depends on oxidation state; and ferrocene/ferrocenium and related metal–ligand complexes used to build molecular switches. Redox-controlled conductive materials and electrochromic devices rely on redox transitions to modulate conductivity and color. In biology and nanomedicine, redox-controlled release systems exploit intracellular redox gradients for targeted delivery.

Measurement and control are typically achieved with electrochemical methods, such as cyclic voltammetry or controlled-potential electrolysis, often complemented by spectroscopic monitoring in spectroelectrochemistry. The term highlights dependence of function on redox balance rather than solely on composition.