pustulosapsoriasis

Pustulosapsoriasis, also known as generalized pustular psoriasis or von Zumbusch psoriasis, is a severe and rare form of psoriasis. It is characterized by the sudden onset of widespread red skin covered in fluid-filled pustules. These pustules are typically sterile, meaning they do not contain bacteria. Pustulosapsoriasis can occur in both children and adults.

The condition often presents with systemic symptoms such as fever, fatigue, rapid heart rate, and general malaise. It can be triggered by various factors, including infections, stress, certain medications (like lithium or corticosteroids), and pregnancy. Withdrawal from systemic corticosteroid treatment can also precipitate an episode.

Diagnosis is typically made based on clinical presentation, and sometimes a skin biopsy may be performed to confirm the diagnosis and rule out other conditions. Pustulosapsoriasis is considered a medical emergency due to potential complications such as dehydration, electrolyte imbalances, kidney failure, and cardiac dysfunction.

Treatment aims to manage the acute episode and prevent recurrence. This often involves hospitalization and the administration of systemic medications, such as acitretin, cyclosporine, or biologics. Supportive care to manage fever, hydration, and electrolyte balance is also crucial. Once the acute phase subsides, patients may transition to less aggressive treatments for their underlying psoriasis.