plasmarakkude
Plasmarakkude, known in English as plasma cells, are specialized antibody-secreting cells derived from B lymphocytes and essential to the adaptive immune response. They develop after B cells encounter an antigen and undergo activation, usually within germinal centers of lymphoid tissues, then migrate to the bone marrow and other tissues where they can persist long term.
Morphology and function: Plasma cells are typically large, with an eccentric nucleus and abundant basophilic cytoplasm.
Phenotype and markers: In humans, plasma cells commonly express high levels of surface markers such as CD38
Clinical relevance: Abnormal proliferation or malignant transformation of plasma cells leads to conditions such as multiple