p160SRC

p160SRC is a protein commonly cited in the literature as a member of the Src family of non-receptor protein tyrosine kinases. In many contexts, the name reflects historical or experimental labeling of the Src kinase protein, with the more widely used designation being c-Src or Src encoded by the SRC gene in humans. The Src family kinases are intracellular signaling enzymes that regulate pathways controlling cell growth, differentiation, survival, adhesion, and motility.

Structurally, Src family kinases share a modular layout that includes an N-terminal region subject to lipid modification for membrane association, followed by SH3 and SH2 regulatory domains and a C-terminal protein tyrosine kinase domain. The activity of Src kinases is tightly regulated by phosphorylation: in the inactive state, a C-terminal regulatory tyrosine keeps the kinase in a closed conformation; disruption of this site and subsequent autophosphorylation of the activation loop promote kinase activity. Activation can be influenced by interactions with focal adhesion components, growth factor receptors, and integrins, linking extracellular cues to cytoskeletal organization and gene expression.

Biological roles attributed to Src kinases include regulation of cell adhesion, migration, proliferation, and survival. Dysregulation or overexpression of Src family activity is associated with oncogenesis and metastatic progression in several cancers. Consequently, Src inhibitors have been investigated in clinical trials as potential cancer therapies, though therapeutic outcomes vary by tumor type and context.

p160SRC, when encountered in the literature, generally refers to the same protein family and is usually discussed in relation to Src signaling pathways, their regulation, and their implications in disease. See Src family kinases for related members such as yes, fyn, and lyn.