osteoklastresorption
Osteoklastresorption, or osteoclast-mediated bone resorption, is the process by which osteoclasts dissolve mineralized bone matrix during bone remodeling. Osteoclasts are large, multinucleated cells of the monocyte–macrophage lineage that attach to bone surfaces at a sealing zone and form a specialized apical membrane called the ruffled border to create a resorption lacuna.
Resorption begins with adhesion to the mineralized surface, followed by acidification and enzymatic degradation. Proton pumps
Resorption is tightly regulated by signaling from osteoblast lineage cells. RANKL, produced by osteoblasts and stromal
Clinical relevance: balanced osteoklast resorption is essential for skeletal integrity; excessive resorption contributes to osteoporosis and
Laboratory assessment may use bone turnover markers, histology, or in vitro assays measuring resorption pits on