oksidatiivisilta

Oksidatiivisilta, also known as oxidative stress, refers to a condition in which the production of reactive oxygen species (ROS) or reactive nitrogen species (RNS) exceeds the body's ability to neutralize them. This imbalance can lead to oxidative damage, where ROS and RNS react with cellular components, such as proteins, lipids, and DNA, causing cellular dysfunction and potentially leading to various diseases.

Oxidative stress is a significant factor in the development and progression of numerous health conditions, including cardiovascular diseases, neurodegenerative disorders, cancer, and chronic inflammatory diseases. It can be caused by various factors, such as exposure to environmental toxins, radiation, and certain medications, as well as by physiological processes like inflammation and aging.

The body has several defense mechanisms to counteract oxidative stress, including antioxidant enzymes like superoxide dismutase, catalase, and glutathione peroxidase, as well as non-enzymatic antioxidants like vitamins C and E, and selenium. However, these defenses can become overwhelmed under conditions of high oxidative stress, leading to oxidative damage.

Research into oxidative stress and its role in disease has led to the development of various therapeutic strategies aimed at reducing oxidative damage and promoting antioxidant defenses. These include the use of antioxidant supplements, dietary interventions, and pharmacological agents that target specific pathways involved in oxidative stress. Understanding the mechanisms underlying oxidative stress and its impact on health is crucial for developing effective preventive and therapeutic approaches to combat this condition.