nucleoskeleton
The nucleoskeleton is a network of filamentous proteins inside the cell nucleus that provides mechanical support, helps maintain nuclear shape, and contributes to the organization and regulation of chromatin. It is distinct from the cytoskeleton but interacts with it through the nuclear envelope. The nucleoskeleton includes the nuclear lamina, nuclear actin and actin-related networks, and other scaffolding proteins that share links to chromatin and the nuclear envelope.
A central element is the nuclear lamina, a dense mesh underlying the inner nuclear membrane composed mainly
Functionally, the nucleoskeleton provides structural resilience to mechanical stress, maintains nuclear morphology, and constrains or guides
Clinical and research relevance: Alterations in lamins or lamin-associated proteins underlie several diseases, including muscular dystrophy,