nucleophisia
Nucleophisia is a term used in some chemical literature to describe the inherent ability of a species to donate electron density to an electrophilic center, functioning similarly to the more common concept of nucleophilicity. In those contexts, nucleophisia is discussed as a property that influences reaction pathways, rates, and selectivity in nucleophile–electrophile encounters.
The term is not universally standardized and may be applied with varying nuances across sources. Some authors
Determinants of nucleophisia include charge, polarizability, and the energy and shape of the highest occupied molecular
Measurement of nucleophisia is typically inferred from kinetics with standard electrophiles or derived from computational descriptors.
Examples of species with high nucleophisia in many solvent contexts include cyanide, thiolates, alkoxides, and amine