nociceptorsfree
Nociceptorsfree is a term used to describe tissues or organisms that lack functional nociceptors, the sensory neurons that detect potentially damaging stimuli and initiate nociceptive signaling.
In mammals, nociceptors reside in the peripheral nervous system and comprise small-diameter neurons that transmit signals
Nociceptorsfree may be discussed as a hypothetical or experimental designation for systems in which nociceptor presence
Clinically, some conditions such as congenital insensitivity to pain involve profound impairment of nociception, but rarely
The concept is used mainly in research to understand pain signaling, nociceptor contributions to tissue injury
Analgesia and anesthesia differ from a nociceptorsfree state because they modulate signaling without eliminating nociceptors.