nAChRantagonist
nAChRantagonist refers to any substance that inhibits nicotinic acetylcholine receptors (nAChRs), thereby blocking acetylcholine from activating the receptor and preventing ion channel opening. By this action, nAChRantagonists reduce postsynaptic depolarization at cholinergic synapses in the central nervous system and at the neuromuscular junction, and can limit transmitter release at certain presynaptic sites.
nAChRs are pentameric ion channels composed of various alpha and other subunits, with distinct subtypes in
Common examples include competitive NMJ blockers such as d-tubocurarine, pancuronium, and vecuronium, used clinically to provide
Clinical and research relevance: nAChR antagonists are employed to facilitate surgical procedures via neuromuscular blockade and