mátrixmetalloproteinázok
Mátrixmetalloproteinázok, commonly abbreviated as MMPs, are a family of enzymes that play a crucial role in the breakdown of extracellular matrix components. These enzymes are zinc-dependent endopeptidases, meaning they require a zinc ion for their catalytic activity and cleave peptide bonds within proteins. The primary function of MMPs is to remodel and degrade the extracellular matrix, a complex network of proteins and other molecules that provides structural support to tissues and cells.
The MMP family is extensive, with over 20 different types identified in humans, each exhibiting distinct substrate
However, dysregulation of MMP activity is implicated in numerous pathological conditions. Overexpression or aberrant activation of