mukokiliäre

Mukokiliäre refers to the mucociliary escalator, a physiological mechanism in the respiratory tract responsible for clearing mucus and inhaled particles. It consists of two main components: mucus-producing goblet cells and ciliated epithelial cells lining the airways. Goblet cells secrete mucus, a sticky substance that traps foreign particles, pathogens, and debris. The ciliated cells have tiny, hair-like projections called cilia that beat in a coordinated, wave-like fashion. This synchronized beating propels the mucus layer upward, away from the lungs and towards the pharynx, where it can be swallowed or expectorated.

This mucociliary clearance system is crucial for maintaining a healthy respiratory system. It acts as a primary defense against inhaled irritants and infections, preventing them from reaching the delicate lung tissue. Various factors can impair the function of the mukokiliäre, including smoking, certain infections, dehydration, and genetic conditions like cystic fibrosis. When the mucociliary escalator is compromised, mucus can accumulate in the airways, leading to increased susceptibility to respiratory infections, chronic cough, and inflammation. Therapies aimed at improving mucociliary clearance often focus on hydration, airway clearance techniques, and medications that thin mucus or stimulate ciliary function.