macrophagederived
Macrophage-derived is a term used in biology to describe molecules, vesicles, or other factors that originate from macrophages, a diverse group of immune cells derived from monocytes and residing in tissues. Macrophages participate in host defense, tissue remodeling, and homeostasis, and their secretory profile adapts to local cues, a phenomenon known as polarization into pro-inflammatory M1 or anti-inflammatory M2 states. The macrophage-derived milieu includes cytokines such as TNF-α, IL-1β, IL-6, and IL-12; anti-inflammatory IL-10; chemokines such as CCL2 (MCP-1) and CXCL8; growth factors such as VEGF and TGF-β; proteases like MMP-9; lipid mediators; and extracellular vesicles such as exosomes carrying proteins and microRNAs.
In addition to soluble mediators, macrophages release extracellular vesicles that influence neighboring cells and modulate immune
The descriptor is used to specify cellular origin rather than a single molecule. Macrophage-derived mediators play