lipodystrofiasairauksiin

Lipodystrophies are a group of rare genetic disorders characterized by abnormal fat distribution and metabolism. These conditions affect the body's ability to store and utilize fat, leading to various symptoms and complications. Lipodystrophies can be classified into two main categories: lipodystrophy with secondary insulin resistance and lipodystrophy with primary insulin resistance.

Lipodystrophy with secondary insulin resistance, also known as partial lipodystrophy, is characterized by the loss of fat in specific areas of the body, such as the face, arms, and legs, while sparing other areas like the trunk and buttocks. This type of lipodystrophy is often associated with insulin resistance, which can lead to metabolic syndrome, diabetes, and cardiovascular disease.

Lipodystrophy with primary insulin resistance, also known as generalized lipodystrophy, is characterized by the loss of fat throughout the entire body. This type of lipodystrophy is often associated with severe insulin resistance and can lead to life-threatening complications, such as lipodystrophy syndrome, which includes features like muscle weakness, elevated blood pressure, and increased risk of heart disease.

The exact cause of lipodystrophies is not fully understood, but it is believed to be due to genetic mutations that affect fat metabolism and insulin signaling. Treatment for lipodystrophies focuses on managing symptoms and complications, such as insulin resistance, diabetes, and cardiovascular disease. This may include lifestyle modifications, such as diet and exercise, as well as medications, such as insulin and lipid-lowering drugs. In some cases, stem cell therapy may be used to restore fat tissue and improve insulin sensitivity.