kokonaisannokseen

Kokonaisannokseen is the illative form of the Finnish noun kokonaisannos, which means the total dose. The term appears in scientific and clinical contexts, particularly in pharmacology, toxicology, and research reporting, where discussions focus on the cumulative exposure of a subject to a substance over a defined period. As a grammatical form, kokonaisannokseen itself denotes movement toward or reference to the total dose, and its meaning is determined by the surrounding wording (for example, kokonaisannokseen liittyvät riskit, risks related to the total dose).

In practice, kokonaisannokseen is used to connect statements to the concept of the total dose rather than describing a single administered amount. It often appears in phrases that assess safety, efficacy, or regulatory considerations in relation to the overall exposure rather than per-dose amounts. The term is closely related to kumulatiivinen annos (cumulative dose) and in some texts may be used interchangeably with discussions of total exposure, though kumulatiivinen annos emphasizes the summation over time.

Etymology: kokonais- means total or whole, annos means dose, and the illative suffix -seen marks direction toward or reference to the total dose. See also kokonaisannos and kumulatiivinen annos for related concepts in Finnish pharmacology and toxicology.