koaktywatory
Koaktywator, in biology often translated as coactivator, is a molecule or protein that enhances the activity of another regulator, most commonly transcription factors, without binding to DNA directly. Koaktywatory act by increasing the efficiency of transcriptional activation and by shaping the chromatin environment to facilitate gene expression.
Mechanism and functional principles: Koaktywatory do not typically recognize specific DNA sequences themselves. Instead, they interact
Examples and contexts: Classic examples include the p160/src family coactivators (SRC-1, SRC-2, SRC-3) that enhance signaling
Significance: Koaktywatory are essential for the regulation of development, metabolism, hormone responses, and cellular differentiation. Dysregulation
Research and identification: Koaktywatory are typically studied by biochemical interaction assays, chromatin assays, and genetic approaches