ispinesibspecific
Ispinesibspecific is a term used to describe properties or effects that are specific to the small-molecule drug ispinesib, particularly its selective inhibition of kinesin spindle protein (KSP), also known as KIF11. The concept centers on the idea that ispinesib targets a mitotic motor protein rather than general microtubule dynamics, yielding a distinct pharmacologic profile.
Ispinesib acts as a selective inhibitor of KSP, a motor protein essential for proper bipolar spindle formation
The term ispinesibspecific also encompasses the drug’s pharmacodynamic and biomarker effects that reflect KSP inhibition, such
Clinical development of ispinesib has included phase II trials in various solid tumors. While some clinical
In research contexts, ispinesibspecific assays and readouts are used to measure KSP activity or the cellular