iPSCk
iPSCk is a term that refers to induced pluripotent stem cells that have been reprogrammed or derived using a specific set of transcription factors, often referred to as the "Yamanaka factors." These factors, typically Oct4, Sox2, Klf4, and c-Myc, are crucial for initiating the reprogramming process. When these factors are introduced into somatic cells, such as skin cells or blood cells, they can revert the cells to a pluripotent state. Pluripotent stem cells possess the remarkable ability to differentiate into virtually any cell type found in the body.
The development of iPSCs by Shinya Yamanaka in 2006 revolutionized the field of stem cell research. Prior