hüaluronidaasi
Hyaluronidase is an enzyme that catalyzes the breakdown of hyaluronan, a component of the extracellular matrix. It is found in various organisms, including bacteria, viruses, and animals, and plays a significant role in many biological processes. The enzyme is often referred to as "spreading factor" due to its ability to increase the permeability of tissues, facilitating the spread of substances through the extracellular matrix.
Hyaluronidase exists in several isoforms, which can be classified into two main types: animal hyaluronidases and
In humans, hyaluronidase is encoded by several genes, including HYAL1, HYAL2, and SPAM1 (which encodes PH-20).
Hyaluronidase has numerous applications in medicine and biotechnology. It is used as an adjuvant in subcutaneous
The enzyme's activity is regulated by various factors, including pH, temperature, and the presence of specific