PH20
PH20 is a designation used in different contexts, most notably in reproductive biology. In this field, PH-20 refers to a sperm membrane hyaluronidase, commonly called PH-20 hyaluronidase or SPAM1. This enzyme is expressed on the surface of mammalian sperm and functions to degrade hyaluronic acid in the extracellular matrix of the cumulus surrounding the oocyte, helping sperm penetrate toward the egg and participate in fertilization. The human gene SPAM1 encodes this enzyme. PH-20 activity is a subject of study in fertility research and contraception, as it plays a role in the acrosome reaction and sperm–egg interaction.
Outside biology, the designation PH20 can appear as a product code, model number, or brand name in