hypotenziin
Hypotenziin is a rare genetic disorder characterized by a deficiency in the production of angiotensinogen, a protein involved in the regulation of blood pressure. This deficiency leads to a reduced ability of the body to produce angiotensin II, a potent vasoconstrictor that helps maintain blood pressure. Individuals with hypotenziin typically experience symptoms such as severe hypotension, dizziness, and fainting spells, often triggered by standing up or physical exertion. The disorder is inherited in an autosomal recessive manner, meaning that both copies of the gene responsible for angiotensinogen production must be mutated for the condition to occur. Diagnosis of hypotenziin is typically made through genetic testing, which identifies mutations in the AGT gene. Treatment options for hypotenziin are limited and primarily focus on managing symptoms, including the use of vasopressors to increase blood pressure and lifestyle modifications to prevent episodes of hypotension. Prognosis varies, but many individuals with hypotenziin can lead relatively normal lives with appropriate management.