glyserolimolekyylin
glyserolimolekyylin is a synthetic nitrogen‑containing heterocycle discovered during a high‑throughput screen of bioactive compounds in the early 2000s. The molecule contains a fused pyrrolo[2,3‑c]pyridine scaffold linked via an amidine connection to a 5‑methyloxazole ring, giving it the systematic name 5‑(2‑(3‑methyl‑1H‑pyrrolo[2,3-c]pyridin‑5‑yl)amino)‑1‑(5‑methyloxazol‑3‑yl)pentan‑1‑amine. Chemists reported that glyserolimolekyylin can be prepared in three steps from commercially available 2‑aminopyridine, using a Suzuki cross‑coupling, copper‑mediated amidation, and a late‑stage N‑oxide reduction.
Research has shown that glyserolimolekyylin is a competitive inhibitor of the enzyme phosphatidylinositol 3‑kinase (PI3K), with
Toxicological data in rodents suggest a median lethal dose (LD50) of >500 mg/kg when administered orally, with