fluvoxamina

Fluvoxamine, sometimes called fluvoxamina, is a selective serotonin reuptake inhibitor (SSRI) used primarily for obsessive-compulsive disorder (OCD). It is sold under Luvox and Luvox CR and is prescribed for some anxiety disorders in certain countries. Its effect comes from blocking serotonin reuptake, increasing brain serotonin; it also binds sigma-1 receptors, which may influence its profile.

Indications and dosing: The main indication is OCD. Dosing is individualized; starting at 25 mg daily with gradual increases to 100–300 mg per day, divided if needed. Some regimens use higher totals. Benefit often takes several weeks. As with other SSRIs, treatment should continue long enough to assess response, and withdrawal should be gradual when stopping.

Pharmacokinetics and interactions: Fluvoxamine is taken orally and metabolized in the liver. It is a potent inhibitor of several cytochrome P450 enzymes, especially CYP1A2 and 2C19, which can raise levels of other drugs. Do not use with monoamine oxidase inhibitors or within a safe window after MAOIs due to serotonin syndrome risk. Caution with anticoagulants and other serotonergic or sedating medicines.

Adverse effects and safety: Common adverse effects include nausea, dry mouth, insomnia or sedation, dizziness, and sexual dysfunction. Others include sweating, GI upset, and weight changes. Hyponatremia can occur, particularly in older adults. As with other SSRIs, abrupt discontinuation can cause withdrawal symptoms; gradual taper is recommended. Safety in pregnancy and in children varies by region; consult a clinician.

Availability and research: Fluvoxamine is available as a generic in many regions. It has strong evidence for OCD; data for depression and other anxiety disorders vary and depend on guidelines and individual response.