doramectin

Doramectin is a macrocyclic lactone antiparasitic agent primarily used in veterinary medicine to control a broad spectrum of internal and external parasites in livestock. It is derived from avermectins, which are natural products produced by the bacterium Streptomyces avermitilis. Doramectin functions by binding to glutamate-gated chloride channels in the nervous system of parasites, leading to increased chloride ion influx, hyperpolarization, paralysis, and eventual death of the parasites.

This compound is commonly administered via subcutaneous injection or topical formulations, depending on the target species and specific parasite infestations. It exhibits a persistent antiparasitic effect, which allows for less frequent dosing schedules. Doramectin is effective against various parasites, including gastrointestinal nematodes, lungworms, and some external pests like mites and lice.

In veterinary applications, doramectin is used primarily in cattle, sheep, and goats. It has a favorable safety profile when used according to recommended dosages but should be applied with caution to avoid resistance development and ensure proper withdrawal periods for meat and milk products.

As with other macrocyclic lactones, doramectin may cause adverse reactions in some animals, including hypersensitivity and neurotoxicity in cases of overdose. Its use is regulated and requires veterinarian oversight to ensure efficacy and animal welfare.

Research into newer formulations and combinations continues to expand the utility of doramectin in parasite control programs, contributing to sustainable livestock management practices worldwide.