dopaminutslippet
Dopaminutslippet, or dopamine release, is the process by which dopamine is released from presynaptic terminals into the synaptic cleft in the brain. It is a central mechanism of dopaminergic signaling that influences movement, reward, motivation, and learning.
In response to an action potential, voltage-gated calcium channels open and trigger the fusion of dopamine-containing
Major dopaminergic pathways include the mesolimbic system (ventral tegmental area to nucleus accumbens), the mesocortical system
Regulation and pharmacology are clinically important. Drugs can elevate extracellular dopamine by inhibiting DAT (e.g., cocaine)