dECM
Decellularized extracellular matrix (dECM) is ECM derived from biological tissue after cellular components have been removed, leaving a biocompatible scaffold that preserves the native three-dimensional architecture and biochemical cues of the tissue. dECM can be sourced from various tissues and organs, including skin, blood vessels, heart, liver, lung, intestine, cartilage, and whole organs. The resulting material can be used in solid scaffold form or processed into hydrogels or injectable formulations for regenerative applications.
Preparation and characteristics
dECM is produced by decellularizing tissue using physical, chemical, and enzymatic methods that aim to remove
dECM serves as a scaffold for tissue engineering and regenerative medicine, enabling recellularization with patient-derived cells.
Key challenges include achieving complete decellularization with minimal ECM damage, controlling batch-to-batch variability, balancing mechanical strength