collagenoses

Collagenoses are a group of chronic autoimmune diseases that affect connective tissues. Connective tissue is found throughout the body and provides support and structure to organs and other tissues. In collagenoses, the immune system mistakenly attacks the body's own healthy connective tissue, leading to inflammation and damage.

The term "collagenosis" is derived from collagen, a major protein component of connective tissue. While many connective tissues are involved, the inflammatory processes often target blood vessels, skin, joints, muscles, and internal organs. The specific manifestations and severity of collagenoses can vary widely, making diagnosis and treatment challenging.

Common examples of collagenoses include systemic lupus erythematosus (SLE), scleroderma, polymyositis, dermatomyositis, and Sjögren's syndrome. These conditions can present with a diverse range of symptoms, such as fatigue, joint pain, skin rashes, muscle weakness, and organ-specific dysfunction. The underlying cause of collagenoses is not fully understood but is thought to involve a combination of genetic predisposition and environmental triggers. Treatment typically focuses on managing symptoms and suppressing the overactive immune response through medications like corticosteroids and immunosuppressants.