colchicineresistance
Colchicine resistance refers to the lack of adequate clinical response to colchicine therapy at doses that are otherwise tolerated. It is discussed most often in familial Mediterranean fever (FMF) but can also be described in gout and recurrent pericarditis. It is important to distinguish resistance from intolerance (where adverse effects limit dose) and from nonadherence or misdiagnosis of disease activity.
Causes and potential mechanisms include nonadherence, underdosing, or drug interactions that reduce colchicine exposure (for example,
Diagnosis and evaluation involve confirming adherence, reviewing dosing, and examining drug interactions and absorption. Exclude intolerance
Management strategies depend on the underlying condition. In FMF with colchicine resistance, escalation to higher doses