chlorophosphoraneDMF

ChlorophosphoraneDMF is a solution consisting of chlorophosphorane dissolved in N,N-dimethylformamide (DMF). It is used in organic synthesis as a chlorinating and activating reagent, enabling transformations that introduce chlorine functionality under relatively mild conditions.

Typically, chlorophosphoraneDMF is prepared by dissolving solid chlorophosphorane in anhydrous DMF to form a defined concentration. The solution is moisture sensitive, and handling is conducted under inert atmosphere to preserve reactivity and minimize hydrolysis.

In use, the reagent functions as a source of chlorine transfer in a variety of substrates and reaction contexts. It is valued for its compatibility with common organic functional groups and for the ability to operate within DMF, which helps stabilize reactive intermediates. The exact scope of substrates and conditions can vary among studies and applications.

Safety and handling require standard laboratory precautions. The material is typically corrosive and reacts with water or alcohols to release corrosive byproducts such as hydrogen chloride. It should be used in a well-ventilated fume hood, with appropriate personal protective equipment, and stored sealed under inert gas in a cool, dry place away from moisture.

See also: chlorophosphorane, dimethylformamide, phosphorus–halogen reagents. Further details and specific procedure guidance are found in the primary literature and supplier documentation.