breastovarian

The term breastovarian refers to a genetic mutation that significantly increases a person's risk of developing breast cancer and ovarian cancer. This mutation is most commonly found in the BRCA1 and BRCA2 genes. These genes are known as tumor suppressor genes, meaning they normally help repair damaged DNA and play a role in keeping cells from growing and dividing too rapidly or in an uncontrolled way. When a mutation occurs in these genes, this repair function is impaired, leading to a higher chance of developing cancer.

Individuals with a breastovarian mutation may inherit it from either parent. The lifetime risk of developing breast cancer for women with BRCA1 or BRCA2 mutations can be as high as 87%, and the risk of ovarian cancer can be as high as 44%. Men can also carry these mutations and have an increased risk of breast cancer and other cancers such as prostate and pancreatic cancer. Genetic testing is available to identify these mutations.

If a breastovarian mutation is identified, medical professionals can recommend various strategies to manage the increased risk. These may include more frequent screenings for breast and ovarian cancer, chemoprevention medications, or prophylactic surgeries such as mastectomy and oophorectomy (removal of ovaries and fallopian tubes) to significantly reduce cancer risk. Understanding one's genetic predisposition through testing allows for personalized risk management and early detection strategies.