bioavailabilitydetermine
Bioavailability determination, in pharmacology and pharmaceutical science, is the process of assessing the extent and rate at which an administered substance enters systemic circulation and becomes available at the site of action. The two commonly used concepts are absolute bioavailability, the fraction of an administered dose that reaches systemic circulation compared to an intravenous reference dose, and relative bioavailability, the comparison between two non-intravenous formulations.
In vivo methods involve pharmacokinetic studies in humans or animals, with blood sampling to derive concentration–time
Bioavailability is influenced by formulation, physicochemical properties, and physiological factors such as gastric pH, gut motility,